Research presented on June 2 at the American College of Sports Medicine’s Annual Meeting in Boston (and to be published in the Journal of the American Medical Athletic Association later this month) has led to the development of a new sports nutrition product aimed at preventing and treating muscle cramps. The new HotShot sports shot is aimed at stopping cramping from a neuromuscular level, not from a muscular dehydration point of view.

HotShot was developed by a Nobel Prize-winning neuroscientist and endurance athlete in collaboration with a Harvard Medical School neurobiology professor. The a 1.7-ounce sports shot is comprised of a proprietary formula of GMO-free organic ingredients with a pungent kick—a mixture that includes organic spice extracts, lime juice concentrate, pectin, sea salt, organic cane sugar, gum arabic and filtered water.

So far the brand has several high-profile athletes onboard, including elite U.S. runners Shalane Flanagan, Amy Cragg, Colleen Quigley and Evan Jager.

The company says HotShot has a formula of strong TRP activators that has shown a statistically significant reduction in muscle cramp intensity compared to placebo in two distinct muscle cramp models: 1) electrically induced muscle cramps; and 2) an innovative new model developed by Penn State University in which healthy volunteers maximally contracted one calf muscle until cramping occurred.

A field study of healthy, cramp-prone athletes who consumed HotShot 15-30 minutes before their normal training sessions showed a 50 percent or more reduction in the frequency of exercise-associated muscle cramps compared to the observed baseline frequency. In addition, the athletes reported a quicker return to training when a cramp episode did occur.

“I am not aware of any other consumer product that has demonstrated significant efficacy in mitigating muscle cramps in such a rigorous double-blind scientific study,” said Larry Kenney, Ph.D., FACSM, Marie Underhill Noll Chair in Human Performance and Professor of Physiology and Kinesiology at Penn State University.

HotShot is available online and also at select running and cycling stores in Denver/Boulder, Colo., Los Angeles and Boston for $7 per bottle or in six-pack ($35) and 12-pack ($65) boxes.